Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
Identifieur interne : 003C79 ( Main/Exploration ); précédent : 003C78; suivant : 003C80Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
Auteurs : Valtteri Kaasinen [Finlande] ; Sargo Aalto [Finlande] ; Kjell N Gren [Finlande] ; Juha O. Rinne [Finlande]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-11.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Cerebral Cortex (physiopathology), Cerebral Cortex (radionuclide imaging), D2 Dopamine receptor, Dominance, Cerebral (physiology), Dopamine Antagonists (diagnostic use), Exploratory Behavior (physiology), Female, Humans, Impulsive Behavior (physiopathology), Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Novelty, PET, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Personality, Positron-Emission Tomography, Pyrrolidines (diagnostic use), Receptors, Dopamine D2 (physiology), Reproducibility of Results, Salicylamides (diagnostic use), Statistics as Topic, Temperament, dopamine D2 receptor, insular cortex, personality.
- MESH :
- chemical , diagnostic use : Dopamine Antagonists, Pyrrolidines, Salicylamides.
- physiology : Dominance, Cerebral, Exploratory Behavior, Receptors, Dopamine D2.
- physiopathology : Cerebral Cortex, Impulsive Behavior, Parkinson Disease.
- radionuclide imaging : Cerebral Cortex, Parkinson Disease.
- Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Reproducibility of Results, Statistics as Topic, Temperament.
Abstract
Novelty seeking is a temperament trait characterized by impulsiveness and exploratory behavior. Dopamine has been suggested to be the primary neurotransmitter modulator of novelty seeking, and in young healthy subjects, a correlation between increased novelty seeking and decreased insular cortical dopamine D2 receptor availability has been reported. The proposed link between dopamine deficiency and reduction in novelty seeking in Parkinson's disease is controversial. The present study examined whether a link between insular D2 receptor availability and novelty seeking can be replicated in Parkinson's disease patients. [11C]FLB 457 positron emission tomography imaging was carried out in 28 patients with Parkinson's disease, and the data were analyzed using voxel‐based statistical analysis. The results demonstrated a negative correlation between the novelty seeking score and the dopamine D2 availability bilaterally in the insular cortex (corrected P = 0.001; r = −0.74 [right hemisphere]; r = −0.66 [left hemisphere]). The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross‐cultural, independent of age, and unaffected by dopaminergic degeneration. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20191
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002968
- to stream Istex, to step Curation: 002968
- to stream Istex, to step Checkpoint: 002660
- to stream PubMed, to step Corpus: 003311
- to stream PubMed, to step Curation: 003311
- to stream PubMed, to step Checkpoint: 003432
- to stream Ncbi, to step Merge: 000F77
- to stream Ncbi, to step Curation: 000F77
- to stream Ncbi, to step Checkpoint: 000F77
- to stream Main, to step Merge: 005637
- to stream PascalFrancis, to step Corpus: 002017
- to stream PascalFrancis, to step Curation: 000D04
- to stream PascalFrancis, to step Checkpoint: 002125
- to stream Main, to step Merge: 005963
- to stream Main, to step Curation: 003C79
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease</title>
<author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
</author>
<author><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
</author>
<author><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E5D97E06EF3A8255E9AEBED9F0E585043C0CDF32</idno>
<date when="2004" year="2004">2004</date>
<idno type="doi">10.1002/mds.20191</idno>
<idno type="url">https://api.istex.fr/document/E5D97E06EF3A8255E9AEBED9F0E585043C0CDF32/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002968</idno>
<idno type="wicri:Area/Istex/Curation">002968</idno>
<idno type="wicri:Area/Istex/Checkpoint">002660</idno>
<idno type="wicri:doubleKey">0885-3185:2004:Kaasinen V:insular:dopamine:d</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15389994</idno>
<idno type="wicri:Area/PubMed/Corpus">003311</idno>
<idno type="wicri:Area/PubMed/Curation">003311</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003432</idno>
<idno type="wicri:Area/Ncbi/Merge">000F77</idno>
<idno type="wicri:Area/Ncbi/Curation">000F77</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F77</idno>
<idno type="wicri:doubleKey">0885-3185:2004:Kaasinen V:insular:dopamine:d</idno>
<idno type="wicri:Area/Main/Merge">005637</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:05-0001340</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002017</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000D04</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002125</idno>
<idno type="wicri:doubleKey">0885-3185:2004:Kaasinen V:insular:dopamine:d</idno>
<idno type="wicri:Area/Main/Merge">005963</idno>
<idno type="wicri:Area/Main/Curation">003C79</idno>
<idno type="wicri:Area/Main/Exploration">003C79</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease</title>
<author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Centre for Cognitive Neuroscience, University of Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2004-11">2004-11</date>
<biblScope unit="vol">19</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1348">1348</biblScope>
<biblScope unit="page" to="1351">1351</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">E5D97E06EF3A8255E9AEBED9F0E585043C0CDF32</idno>
<idno type="DOI">10.1002/mds.20191</idno>
<idno type="ArticleID">MDS20191</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>D2 Dopamine receptor</term>
<term>Dominance, Cerebral (physiology)</term>
<term>Dopamine Antagonists (diagnostic use)</term>
<term>Exploratory Behavior (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Impulsive Behavior (physiopathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Novelty</term>
<term>PET</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Personality</term>
<term>Positron-Emission Tomography</term>
<term>Pyrrolidines (diagnostic use)</term>
<term>Receptors, Dopamine D2 (physiology)</term>
<term>Reproducibility of Results</term>
<term>Salicylamides (diagnostic use)</term>
<term>Statistics as Topic</term>
<term>Temperament</term>
<term>dopamine D2 receptor</term>
<term>insular cortex</term>
<term>personality</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dopamine Antagonists</term>
<term>Pyrrolidines</term>
<term>Salicylamides</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term>
<term>Exploratory Behavior</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Impulsive Behavior</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebral Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Reproducibility of Results</term>
<term>Statistics as Topic</term>
<term>Temperament</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Nouveauté</term>
<term>Parkinson maladie</term>
<term>Personnalité</term>
<term>Récepteur dopaminergique D2</term>
<term>Système nerveux pathologie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Novelty seeking is a temperament trait characterized by impulsiveness and exploratory behavior. Dopamine has been suggested to be the primary neurotransmitter modulator of novelty seeking, and in young healthy subjects, a correlation between increased novelty seeking and decreased insular cortical dopamine D2 receptor availability has been reported. The proposed link between dopamine deficiency and reduction in novelty seeking in Parkinson's disease is controversial. The present study examined whether a link between insular D2 receptor availability and novelty seeking can be replicated in Parkinson's disease patients. [11C]FLB 457 positron emission tomography imaging was carried out in 28 patients with Parkinson's disease, and the data were analyzed using voxel‐based statistical analysis. The results demonstrated a negative correlation between the novelty seeking score and the dopamine D2 availability bilaterally in the insular cortex (corrected P = 0.001; r = −0.74 [right hemisphere]; r = −0.66 [left hemisphere]). The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross‐cultural, independent of age, and unaffected by dopaminergic degeneration. © 2004 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
</country>
<region><li>Finlande occidentale</li>
</region>
<settlement><li>Turku</li>
</settlement>
<orgName><li>Université de Turku</li>
</orgName>
</list>
<tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
</region>
<name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
<name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C79 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C79 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:E5D97E06EF3A8255E9AEBED9F0E585043C0CDF32 |texte= Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |